Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/23463
Title in Portuguese: Side-effects of irinotecan (CPT-11), the clinically used drug for colon cancer therapy, are eliminated in experimental animals treated with latex proteins from calotropis procera (Apocynaceae)
Author: Alencar, Nylane Maria Nunes de
Bitencourt, Flávio da Silveira
Figueiredo, Ingrid Samantha Tavares de
Luz, Patrícia Bastos
Lima-Júnior, Roberto César P.
Aragão, Karoline Sabóia
Magalhães, Pedro Jorge Caldas
Brito, Gerly Anne de Castro
Ribeiro, Ronaldo Albuquerque
Freitas, Ana Paula Fragoso de
Ramos, Marcio Viana
Keywords: Neoplasias do Colo
Colonic Neoplasms
Apocynaceae
Issue Date: Feb-2017
Publisher: Phytotherapy Research
Citation: ALENCAR, N. M. N. de et al. Effects of irinotecan (CPT-11), the clinically used drug for colon cancer therapy, are eliminated in experimental animals treated with latex proteins from Calotropis procera (Apocynaceae). PTR. Phytotherapy Research, London, v. 31, n. 2, p. 312-320, feb. 2017.
Abstract: Intestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for additional 6 days. Animal survival, body weight variation, and diarrhea were registered. After animal sacrifice (day 7 post first injection of CPT-11), intestinal samples were collected to study morphology and inflammatory parameters. Animals given LP exhibited improved parameters (survival, body weight, and absence of diarrhea) as compared with the CPT-11 control. The severity of IM observed in animals given CPT-11 was reduced in animals treated with LP. Treatment with LP also prevented the reduction in the villus/crypt ratio promoted by CPT-11. The rise in MPO activity and pro-inflammatory cytokines, over-contractility of the smooth muscle, and diarrhea were all abrogated in LP-treated mice. Markedly reduced immunostaining intensity for COX-2, TNF-α, IL-1β, iNOS, and NF-κB was observed in the intestinal tissue of animals treated with LP. The side-effects of CPT-11 were eliminated by LP treatment in experimental animals and improved clinical parameters characteristic of IM All known biochemical pathogenesis. C
URI: http://www.repositorio.ufc.br/handle/riufc/23463
ISSN: 0951-418X
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