Investigação química e farmacológica dos constituintes químicos de Acnistus arborescens

Abstract

This work describes the results of the chemical and pharmacological investigation of the ethanol and acetone extracts of Acnistus arborescens leaves grown in the Center for Studies and Research in Urban Agriculture (NEPAU), Department of Agronomy, Federal University of Ceará (UFC). The compounds were isolated by classic chromatography, and high performance chromatography liquid, and their structures were established by spectrometric techniques such as HRMS, IR and 1D and 2D NMR, and comparison with data available in the literature. In this work the pharmacological activities of the isolated compounds also are described. In addition the structural modification of the major compound in order to enhance its therapeutic properties, also is described. Thus, were obtained seven natural withanolides, of which four are unknown, eight reaction products, and the development of a nanoparticulate system -cyclodextrin-withanolide.