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http://repositorio.ufc.br/handle/riufc/21298
Tipo: | Artigo de Periódico |
Título: | B -Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea |
Autor(es): | Vasconcelos, T.B. Ribeiro-Filho, H. V. Lucetti, L. T. Magalhães, P. J. C. |
Palavras-chave: | Monoterpenos;Canais de cálcio;Calcium channels |
Data do documento: | Dez-2016 |
Instituição/Editor/Publicador: | Brazilian journal of medical and biological research |
Citação: | VASCONCELOS, T. B. et al. β-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 49, n. 2, p. 1-9, 2016. |
Abstract: | β-Citronellol is an alcoholic monoterpene found in essential oils such Cymbopogon citratus (a plant with antihypertensive properties). β-Citronellol can act against pathogenic microorganisms that affect airways and, in virtue of the popular use of β-citronellol-enriched essential oils in aromatherapy, we assessed its pharmacologic effects on the contractility of rat trachea. Contractions of isolated tracheal rings were recorded isometrically through a force transducer connected to a data-acquisition device. β-Citronellol relaxed sustained contractions induced by acetylcholine or high extracellular potassium, but half-maximal inhibitory concentrations (IC50) for K+-elicited stimuli were smaller than those for cholinergic contractions. It also inhibited contractions induced by electrical field stimulation or sodium orthovanadate with pharmacologic potency equivalent to that seen against acetylcholine-induced contractions. When contractions were evoked by selective recruitment of Ca2+ from the extracellular medium, β-citronellol preferentially inhibited contractions that involved voltage-operated (but not receptor-operated) pathways. β-Citronellol (but not verapamil) inhibited contractions induced by restoration of external Ca2+ levels after depleting internal Ca2+ stores with the concomitant presence of thapsigargin and recurrent challenge with acetylcholine. Treatment of tracheal rings with L-NAME, indomethacin or tetraethylammonium did not change the relaxing effects of β-citronellol. Inhibition of transient receptor potential vanilloid subtype 1 (TRPV1) or transient receptor potential ankyrin 1 (TRPA1) receptors with selective antagonists caused no change in the effects of β-citronellol. In conclusion, β-citronellol exerted inhibitory effects on rat tracheal rings, with predominant effects on contractions that recruit Ca2+ inflow towards the cytosol by voltage-gated pathways, whereas it appears less active against contractions elicited by receptor-operated Ca2+ channels. |
URI: | http://www.repositorio.ufc.br/handle/riufc/21298 |
ISSN: | On-line 1414-431X |
Aparece nas coleções: | PPGF - Artigos publicados em revistas científica |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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2016_art_tbvasconcelos.pdf | 1,18 MB | Adobe PDF | Visualizar/Abrir |
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