Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/11193
Title in Portuguese: Nutraceutical preconditioning with arginine and oil mixes. Effects on inflammatory mediators, oxidative stress and lipid profile in patients undergoing radical prostatectomy
Author: Tavares, Lílian de Lima
Cavalcante, Karla Pinheiro
Campelo, Márcio Wilker Soares
Coutinho, Leonam Gomes
Medeiros, Silvia Regina Batistuzzo de
Guimarães, Sérgio Botelho
Vasconcelos, Paulo Roberto Leitão de
Keywords: Prostatectomia
Prostatectomy
Oxidative Stress
Estresse Oxidativo
Issue Date: Aug-2014
Publisher: Acta Cirúrgica Brasileira
Citation: TAVARES, L. L. et al. Nutraceutical preconditioning with arginine and oil mixes. Effects on inflammatory mediators, oxidative stress and lipid profile in patients undergoing radical prostatectomy. Acta Cirúrgica Brasileira, São Paulo, v. 29, n. 8, p. 538-543, ago. 2014.
Abstract: ABSTRACTPURPOSE: To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma.METHODS: Twenty-six men scheduled for radical prostatectomy were randomized into three groups and treated as follows: Group 1 (skim milk, 0% fat), Group 2 (supplement with ω6:ω3 ratio of 8:1 and arginine) and Group 3 (supplement with high ω9:ω6 ratio of 3.2:1 and low ω6:ω3 ratio of 1.4:1 and arginine). Patients received skin milk or supplements twice a day (200 ml) during five days prior to surgery. Peripheral venous blood samples were collected at three different timepoints: five days before surgery (PRE), before anesthesia induction (IND) and on the 2nd postoperative day (POS). Parameters analyzed included inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α), antioxidants (catalase), lipid profile and heat shock protein (HSP-27).RESULTS: There were no significant differences between groups on inflammatory mediators and antioxidant parameters. However, lipid profile values (Cholesterol, LDL, Triglycerides, VLDL), were significantly different. CONCLUSION: Preconditioning with arginine and oil mixes containing high ω9:ω6 ratio and low ω6:ω3 ratio, has no effects on inflammatory mediators and oxidative stress in patients undergoing radical prostatectomy. Reduction of cholesterol, triglycerides, LDL and VLDL profiles may be related to the trauma effect.
URI: http://www.repositorio.ufc.br/handle/riufc/11193
metadata.dc.type: Artigo de Periódico
ISSN: 1678-2674 On line
Appears in Collections:DCIR - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2014_art_lltavares.pdf613,86 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.