Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/10304
Title in Portuguese: Ethanol-induced gastric injury : microscopic analysis of the protective effect of frutalin
Author: Abdon, Ana Paula Vasconcellos
Vasconcelos, Renata Prado
Castro, Carolina Araújo
Guedes, Marjorie Moreira
Tomé, Adriana da Rocha
Cardoso, André Luiz Herzog
Santiago, Thiago de Melo
Rebêlo, Luciana Magalhães
Moreira, Renato de Azevedo
Monteiro-Moreira, Ana Cristina de Oliveira
Campos, Adriana Rolim
Keywords: Artocarpus
Etanol
Issue Date: Aug-2014
Publisher: International Journal of Peptide Research and Therapeutics
Citation: ABDON, A. P. V. et al. Ethanol-induced gastric injury : microscopic analysis of the protective effect of frutalin. International Journal of Peptide Research and Therapeutics, v. 20, n. 3, p. 325-332, ago. 2014.
Abstract: Obtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanolinduced gastric injury. The gastroprotective effect of frutalina was evaluated using a murine model of ethanol-induced gastric injury. Damage of the gastric mucosa was assessed morphologically by light, scanning electron and atomic force microscopy. Lymphocyte infiltration, necrosis, disruption of the mucosal structures and epithelial desquamation were observed in the control group. In the group pretreated with frutalina at 0.5 mg/kg, gastroprotection, reduced tissue damage and preserved submucosal and mucosal structures were observed. In conclusion, FTL displayed gastroprotective activity against ethanol-induced gastric injury, preventing the formation of gastric ulcer and reducing epithelial desquamation, glandular damage, mucosal necrosis and infiltration. The observed effects appear to be due to mechanisms previously described for frutalin.
URI: http://www.repositorio.ufc.br/handle/riufc/10304
metadata.dc.type: Artigo de Periódico
ISSN: 1573-3904 (electronic version)
Appears in Collections:DFIFA - Artigos publicados em revista científica

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